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To the Editor:We thank Dr Korppi1Korppi M. Lung function after viral early childhood wheezing.J Allergy Clin Immunol. 2012; 129: 267-268Abstract Full Text Full Text PDF PubMed Scopus (3) Google Scholar for his interest in our recent article.2Guilbert T.W. Singh A.M. Danov Z. Evans M.D. Jackson D.J. Burton R. et al.Decreased lung function after preschool wheezing rhinovirus illnesses in children at risk to develop asthma.J Allergy Clin Immunol. 2011; 128 (e10): 532-538Abstract Full Text Full Text PDF PubMed Scopus (98) Google Scholar We agree that children with early human rhinovirus (HRV) wheezing illnesses demonstrate an obstructive pattern of lung function at ages 4 to 8 years compared with those who did not wheeze with HRV. Furthermore, this relationship persisted after a bronchodilator was administered, demonstrating that the obstructive pattern was not completely reversible. In the Childhood Origins of Asthma (COAST) cohort, we do not have any data on bronchial hyperresponsiveness at ages 4 to 8 years.A predicted forced vital capacity of 93% may be suggestive of restrictive lung disease but not conclusive without confirmation by body plethysmography. Moreover, our data did not show a lower forced vital capacity in children who wheezed with HRV or respiratory syncytial virus compared with those who wheezed with other viruses. However, unlike the COAST cohort, the majority of children in the Finland cohort experienced wheezing illnesses that required hospitalization that may have resulted in a more significant pulmonary insult. To the Editor: We thank Dr Korppi1Korppi M. Lung function after viral early childhood wheezing.J Allergy Clin Immunol. 2012; 129: 267-268Abstract Full Text Full Text PDF PubMed Scopus (3) Google Scholar for his interest in our recent article.2Guilbert T.W. Singh A.M. Danov Z. Evans M.D. Jackson D.J. Burton R. et al.Decreased lung function after preschool wheezing rhinovirus illnesses in children at risk to develop asthma.J Allergy Clin Immunol. 2011; 128 (e10): 532-538Abstract Full Text Full Text PDF PubMed Scopus (98) Google Scholar We agree that children with early human rhinovirus (HRV) wheezing illnesses demonstrate an obstructive pattern of lung function at ages 4 to 8 years compared with those who did not wheeze with HRV. Furthermore, this relationship persisted after a bronchodilator was administered, demonstrating that the obstructive pattern was not completely reversible. In the Childhood Origins of Asthma (COAST) cohort, we do not have any data on bronchial hyperresponsiveness at ages 4 to 8 years. A predicted forced vital capacity of 93% may be suggestive of restrictive lung disease but not conclusive without confirmation by body plethysmography. Moreover, our data did not show a lower forced vital capacity in children who wheezed with HRV or respiratory syncytial virus compared with those who wheezed with other viruses. However, unlike the COAST cohort, the majority of children in the Finland cohort experienced wheezing illnesses that required hospitalization that may have resulted in a more significant pulmonary insult. Lung function after viral early childhood wheezingJournal of Allergy and Clinical ImmunologyVol. 129Issue 1PreviewTo the Editor: Full-Text PDF