Abstract

The author replies:—I am surprised by the voracity with which Dr. Simmons attacked my use of the word “involute” in the opening sentences of my attempt to formulate a hypothesis linking the thymus gland and reproduction. The latest edition of Stedman's Medical Dictionary defines involution as “the return of an enlarged organ … to normal size.”1 Since, in general, the thymus gland increases to a maximum weight at puberty and decreases with advancing age,2 the term “involution” is one that might be (and has been frequently) used. Moreover, it would seem that Dr. Simmons' anger at the use of the word “involute” blinded him to the concept I attempt to present. I, too, believe the thymus gland is a far more important organ than is generally recognized. Thymic peptides may play important roles in the regulation of other endocrine systems such as the reproductive system. If such is the case, then I certainly agree with Dr. Simmons that the term “thymic atrophy” is incorrect.

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