Abstract
History shows that haplotype data have been around for a long time, and their place in the `revolution in population genetics' is questionable. Probably the first use of haplotypes for reconstruction of human evolutionary history was the identification of rhesus haplotypes by R.A. Fisher in the 1940s (Ref. [1]), except that he called them `chromosomes'. The concept was soon extended to other blood-group genes and gene systems, whenever there was a multiplicity of alleles[2]. The word haplotype was introduced over 30 years ago by Ruggero Ceppellini in HLA genetics[3], when only protein analysis was possible. Word and concept have been widely used since, long before DNA analysis.
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