Abstract
We thank Fernandes and associates for their interest in our study 1 Shimada H. Arai S. Nakashizuka H. Hattori T. Yuzawa M. Reduction of anterior chamber contamination rate after cataract surgery by intraoperative surface irrigation with 0.25% povidone-iodine. Am J Ophthalmol. 2011; 151: 11-17 Abstract Full Text Full Text PDF PubMed Scopus (65) Google Scholar and for actually using our method clinically in their cataract surgeries. For periocular disinfection, 10% povidone-iodine is used in Japan, while 5% povidone-iodine is widely used in American and European countries. For conjunctival disinfection, 1% to 5% povidone-iodine is generally used. However, Jiang and associates 2 Jiang J. Wu M. Shen T. The toxic effect of different concentrations of povidone iodine on the rabbit's cornea. Cutan Ocul Toxicol. 2009; 28: 119-124 Crossref PubMed Scopus (74) Google Scholar observed frequent occurrence of corneal epithelial edema in patients when 5% povidone-iodine was used to irrigate the conjunctiva. When they performed studies on rabbits, instillation of 10 drops (0.5 mL) of 2.5% povidone-iodine caused corneal epithelial damage and injection of 0.05 mL of 1.5% povidone-iodine into the anterior chamber resulted in corneal endothelial damage. 2 Jiang J. Wu M. Shen T. The toxic effect of different concentrations of povidone iodine on the rabbit's cornea. Cutan Ocul Toxicol. 2009; 28: 119-124 Crossref PubMed Scopus (74) Google Scholar From these results, they recommended to use 0.5% or 1.0% povidone-iodine for disinfection of the surgical field. Based on detailed investigations, Trost and associates 3 Trost L.W. Kivilcim M. Peyman G.A. Aydin E. Kazi A.A. The effect of intravitreally injected povidone-iodine on Staphylococcus epidermidis in rabbit eyes. J Ocul Pharmacol Ther. 2007; 23: 70-77 Crossref PubMed Scopus (44) Google Scholar concluded that the concentration range of 0.05% to 0.5% povidone-iodine is safe to ocular tissues and highly bactericidal. Reduction of Anterior Chamber Contamination Rate After Cataract Surgery by Intraoperative Surface Irrigation With 0.25% Povidone-IodineAmerican Journal of OphthalmologyVol. 152Issue 2PreviewEditor: Full-Text PDF
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