Abstract
We appreciate Dr Hayreh's interesting comments on our study about the risk of stroke in patients with nonarteritic anterior ischemic optic neuropathy (NA-AION). 1 Lee Y.C. Wang J.H. Huang T.L. Tsai R.K. Increased risk of stroke in patients with nonarteritic anterior ischemic optic neuropathy: a nationwide retrospective cohort study. Am J Ophthalmol. 2016; 170: 183-189 Abstract Full Text Full Text PDF PubMed Scopus (30) Google Scholar Dr Hayreh asked a crucial question: does the development of NA-AION per se result in increased risk of stroke, or not? He also criticized that our observations of the risk of ischemic stroke among the subjects with NA-AION without comorbidities was not statistically different from those without NA-AION. 1 Lee Y.C. Wang J.H. Huang T.L. Tsai R.K. Increased risk of stroke in patients with nonarteritic anterior ischemic optic neuropathy: a nationwide retrospective cohort study. Am J Ophthalmol. 2016; 170: 183-189 Abstract Full Text Full Text PDF PubMed Scopus (30) Google Scholar These findings contradict our conclusion that patients who develop NA-AION have a higher risk of ischemic stroke than those without that. Finally, he concluded that there is no direct association between NA-AION and cerebrovascular disease. Increased Risk of Stroke in Patients With Nonarteritic Anterior Ischemic Optic Neuropathy: A Nationwide Retrospective Cohort StudyAmerican Journal of OphthalmologyVol. 175PreviewI was interested to read the study by Lee and associates1 about the risk of stroke in patients with nonarteritic anterior ischemic optic neuropathy (NA-AION). According to this retrospective cohort study of 414 NA-AION patients, with mean (standard deviation [SD]) age of 55.9 ± 18.6 years, the risk of ischemic stroke among NA-AION patients was 2.0 times higher than in those without NA-AION. They concluded that patients with NA-AION have an increased risk of ischemic stroke, compared with patients without NA-AION, especially older patients with systemic risk factors. Full-Text PDF
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