Abstract
To the Editor: We thank Dr Velez and coauthors for their comments on our article, “Calcinosis cutis, part II: Treatment options.” Autologous stem cell transplantation (ASCT) exerts a positive effect on soft-tissue calcification. We agree with the author's suggestion that ASCT might be a reasonable choice for the treatment of extensive lifestyle-limiting and painful dystrophic calcinosis cutis that does not respond to traditional therapy. In ASCT, conditioning with high-dose cyclophosphamide, antithymocyte globulin, and/or total-body irradiation nullifies the majority of autoreactive effector cells involved in the adaptive and innate immune response, including B and T lymphocytes, monocytes, natural killer cells, and dendritic cells.
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