Reply: Warfarin: Less May Be Better

Abstract

Letters15 August 1997Reply: Warfarin: Less May Be BetterMark A. Crowther, MD, Linda Harrison, RN, and Jack Hirsh, MDMark A. Crowther, MDHamilton Civic Hospitals Research Centre; Hamilton, Ontario L8V lC3, CanadaSearch for more papers by this author, Linda Harrison, RNHamilton Civic Hospitals Research Centre; Hamilton, Ontario L8V lC3, CanadaSearch for more papers by this author, and Jack Hirsh, MDHamilton Civic Hospitals Research Centre; Hamilton, Ontario L8V lC3, CanadaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-4-199708150-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:To address the questions raised by Dr. Adelman and others, the dose-adjustment algorithms used in our study are presented in the (Figure 1). Patients received 5 mg or 10 mg of warfarin on day 1 and day 2; the day 2 dose was reduced only if an excess anticoagulant effect was seen on the INR determination performed 12 to 16 hours after the first warfarin dose was given. The third and subsequent warfarin doses were based on the INR response and were adjusted according to the appropriate algorithm. The mean warfarin doses administered in the 5-mg group were ...