Abstract
Reply to the Commentary on population matched (pm) germline allelic variants of immunoglobulin (IG) loci: relevance in infectious diseases and vaccination studies in human populations
Highlights
We are aware of the complex endeavors required to develop a database for the IG germline alleles
It is generally overlooked that the vast majority of each individual IG gene and allelic variant in other IG databases are single genes, each derived from a single individual
To guide the users, we consistently mention the limitations of our database, which we clearly emphasized in the discussion of our original manuscript
Summary
Sequences of a few genes are updated in the latest version of the human genome, i.e., GRCh38. An additional base present in GRCh37 version of IGHV3-49 and IGHV3-53 reference genes is removed in the GRCh38 version of the human genome. Such differences certainly will impact the alleles for these genes in the pmIG database. As already discussed in our manuscript, we emphasize again that the pmIG dataset was derived from short-read sequencing data and that mapping errors in the duplicated genes may exist, such as the mapping errors mentioned by Collins et al for genes IGHV3-11 and IGHV3-48 [3]. Following unique facts about the pmIG database should be considered by our users before using the pmIG database for
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