Abstract
Letters to the EditorReply to MarcoraMarkus Amann, and Jerome A. DempseyMarkus AmannDepartment of Medicine, University of Utah, Salt Lake City, Utah; , and Jerome A. DempseyJohn Rankin Laboratory of Pulmonary Medicine, University of Wisconsin, Madison, WisconsinPublished Online:01 May 2011https://doi.org/10.1152/japplphysiol.00181.2011MoreSectionsPDF (38 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInEmailWeChat GROUP III/IV MUSCLE AFFERENTS INFLUENCE EFFORT PERCEPTION DURING EXERCISEIntrathecal fentanyl affects a subset of Group III/IV muscle afferents, i.e., those that are μ-opioid receptor sensitive. The percentage of Group III/IV afferents that is opioid receptor sensitive is unknown. Therefore a considerable amount of afferent feedback likely remained intact during our experiments and we cannot quantify the “relative” contribution of muscle afferents to effort perception. Accordingly, the only interpretation of our findings that is useful is that blocking a portion of these afferents had a significant influence on the subjects' perception of the effort during exercise. To us this simply meant that the afferents had some contribution to the subjects' perception!DISCLOSURESNo conflicts of interest, financial or otherwise, are declared by the authors.REFERENCES1. Marcora SM. Role of feedback from Group III and IV muscle afferents in perception of effort, muscle pain, and discomfort. J Appl Physiol; doi:10.1152/japplphysiol.00146.2011.ISI | Google ScholarAUTHOR NOTESAddress for reprint requests and other correspondence: M. Amann, VA Medical Center, 500 Foothill Dr., GRECC 182, Salt Lake City, UT 84148 (e-mail: markus.[email protected]utah.edu). Download PDF Previous Back to Top Next FiguresReferencesRelatedInformationRelated ArticlesRole of feedback from Group III and IV muscle afferents in perception of effort, muscle pain, and discomfort 01 May 2011Journal of Applied PhysiologyCited ByInfluences of Spinal Anesthesia on Exercise Tolerance in Patients with Chronic Obstructive Pulmonary DiseaseAmerican Journal of Respiratory and Critical Care Medicine, Vol. 186, No. 7 More from this issue > Volume 110Issue 5May 2011Pages 1500-1500 Copyright & PermissionsCopyright © 2011 the American Physiological Societyhttps://doi.org/10.1152/japplphysiol.00181.2011History Published online 1 May 2011 Published in print 1 May 2011 Metrics
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