Reply to Kaye and Belley, "Third-Generation Cephalosporin-Resistant Enterobacterales Are Critical Priority Pathogens, Too!"

Abstract

We would like to thank Kaye and Belley (1) for highlighting the importance of developing new antibacterial agents to treat infections caused by third-generation cephalosporin (3GC)-resistant Enterobacterales, which predominantly produce extended-spectrum β-lactamases (ESBLs). 3GC-resistant Enterobacterales have been classified by the World Health Organization (WHO) as critical priority pathogens (2), and we agree that the number of patients and the burden on health care systems is greater for ESBLs than for carbapenem-resistant Gram-negative infections (3).