Reply to: \u201cHistorical pursuits of the language pathway hypothesis of schizophrenia\u201d

Jianfeng Feng,Jingnan Du,Lena Palaniyappan,Jie Zhang

doi:10.1038/s41537-021-00183-y

Abstract

Reply to: \u201cHistorical pursuits of the language pathway hypothesis of schizophrenia\u201d

Highlights

DeLisi highlights the missing historical context of the focus of our study and the lack of evidence linking our choice of language-related genes to the elevated genetic risk for schizophrenia
Given the lack of a priori selection language networks in our study[2], we did not bring up the large body of fMRI and structural literature referred to by Dr DeLisi that focuses on these networks
We concur with Dr DeLisi that “the genetics of schizophrenia remain elusive and is likely to be highly heterogeneous”

Summary

Introduction

DeLisi highlights the missing historical context of the focus of our study and the lack of evidence linking our choice of language-related genes to the elevated genetic risk for schizophrenia. Our selected candidate genes for language-readiness overlap with schizophrenia as well as brain development as listed by Murphy&Benitez-Burraco in their review[17]. In Finnish Family Adoption studies, a family history of schizophrenia in biological parents did not confer an increased risk of formal thought disorders among the children living with adopted parents[27]. The presence of schizophrenia increases the risk of subtle formal thought disorders among family members[28].

Results

Conclusion