Abstract
ing dimensions of nanometers or even tens of nanometers there is a negligible probability of more than one microdosimetric event at the absorbed doses applied in these experiments. Consequently, the yield of DNA damage must be proportional to the absorbed dose. In such domains LET is an especially inadequate index of energy deposition and the yield of DSBs is a complex function of LET that varies with the mass (and hence the velocity) of ions (2). This dependence can be accounted for simply in terms of the energy actually deposited, as specified by the lineal energy, and saturation at high energy concentration (3). For a given species of ions the variation of RBE is relatively small. The shoulders of the survival curves shown must be due to
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