Abstract
This correspondence was written in response to the comments by Young et al. Following careful evaluation of the relevant dataset, each of the points brought up by Young et al. has been addressed in this response. We anticipate this will clarify our findings regarding ERVmch8, an ecotropic endogenous retrovirus that was shown to have cerebellum-specific and age-dependent expression patterns in C57BL/6J mice.
Highlights
This correspondence was written in response to the comments by Young et al Following careful evaluation of the relevant dataset, each of the points brought up by Young et al has been addressed in this response
We suggest a further study is needed to confirm whether the ERVmch[8] locus matches the Emv[2] locus
To help determine whether ERVmch[8] is Emv[2], a set of Southern blot analyses can be performed using the genomic DNAs from various mouse strains, including the mouse strains reported in the studies referenced by Young et al, with probes designed from the “full/complete” ERVmch[8] sequence, in addition to the pEco probe
Summary
This correspondence was written in response to the comments by Young et al Following careful evaluation of the relevant dataset, each of the points brought up by Young et al has been addressed in this response. Young et al contend that Emv[2] is the only endogenous ecotropic murine leukemia virus in C57BL/6J mice, not annotated on the current NCBI reference genome assembly, Build 37.2, and maps to the distal region of chromosome 8 based on previous genetic studies.
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