Abstract
Furini and Domene (1) suggest an “alternative [KK] mechanism for conduction of K+ in potassium channels,” which “has ions at adjacent binding sites” and “allows the possible presence of vacancies, that is, neither K+ ions nor water molecules in certain sites.” They described their mechanism in detail as follows: “Outward conduction is initiated by the ion in S1 moving toward S0 … After that, ions in S4 and S2 move to S3 and S1 … When the innermost ion reaches S4, upward movements of the ion in S3 to S2 and of the outermost ion to the extracellular milieu conclude the conduction event.” Their mechanism, illustrated here in Fig. 1, is fundamentally equivalent to the vacancy-type diffusion mechanism originally put forth by Hodgkin and Keynes (2) as one of two mechanistic possibilities for K+-channel conduction, the other being the knock-on mechanism.
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