Abstract
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Highlights
To Comments: “Molecular Functions of Thyroid Hormone Signaling in Regulation of Cancer Progression and Anti-Apoptosis” Int
Thyroid hormone receptors (TR) including TRα and TRβ contain several domains; these are the amino-terminal A/B that may function as a gene enhancer, the DNA-binding domain (DBD), the hinge region containing the nuclear localization signal and the carboxy-terminal ligand-binding domain (LBD) that binds T3 through activation function-2 (AF-2), which is a surface-exposed hydrophobic included residue from H3 and H5 and is completed by T3-dependent packing of C-terminal H12 against the LBD which affects target genes transcription [3,4]. (Figure 1)
The c-erbAα gene located on chromosome 17 encodes two different TRα isoforms
Summary
To Comments: “Molecular Functions of Thyroid Hormone Signaling in Regulation of Cancer Progression and Anti-Apoptosis” Int. J. Yu-Chin Liu 1,2, Chau-Ting Yeh 3 and Kwang-Huei Lin 1,2,3,4,* 1 Department of Biochemistry, College of Medicine, Chang-Gung University, Taoyuan 333, Taiwan; k1506820@gmail.com 2 Department of Biomedical Sciences, College of Medicine, Chang-Gung University, Taoyuan 333, Taiwan 3 Liver Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan; chauting@adm.cgmh.org.tw 4 Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan * Correspondence: khlin@mail.cgu.edu.tw; Tel./Fax: +886-3-2118263 Received: 30 April 2020; Accepted: 15 May 2020; Published: 19 May 2020
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