Abstract
The observed change in running behavior can be mediated by changes in the planning and selection centers in the basal ganglia as well as in the initiation and execution centers in the brain stem and spinal cord. We have previously shown that CB1 receptors are necessary for short- and long-term potentiation of the frequency of locomotor activity (1‐3). An initial way to tease out the contribution of these different centers is to develop mice with CB1 receptors deleted in specific areas in the central nervous system and to evaluate the behavioral outcome in these mice. Although some pieces are starting to fall in place in term terms of linking cannabinoid receptor-mediated cellular and synaptic mechanisms to circuit operation and
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