Abstract
We appreciate the interest and comments of Dr. Sundström regarding our article “Early cleavage morphology affects the quality and implantation potential of day 3 embryos” (1). There is little information in human studies on the mechanisms by which multinucleated blastomeres are formed. This uncertainty has been stated in a recent study, “it is not always apparent whether multinucleated cells contain separate nuclear structures or a single nucleus that undergoes transient changes in shape” (2). Probably, appearance of two nuclei of similar size in a single blastomere (binucleation; BN) has to be separated from other forms of multinucleation, as there is evidence that these embryos could develop normally (2, 3).
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