Reply: Combined 18F-FDG and Fluoride Approach in PET/CT Imaging: Is There a Clinical Future?

Abstract

Transdiaphragmatic (Pdi) and oesophageal pressures (Pes) are useful in understanding the pathophysiology of the respiratory system. They provide insight into respiratory drive, intrinsic positive end-expiratory pressure, diaphragmatic fatigue and weaning failure. <h3>Background</h3> The use of Pdi and Pes in clinical practice is restricted due to the invasiveness of the technique and the cumbersome equipment needed. On the other hand, diaphragmatic displacement is non-invasively and easily assessed with M-mode ultrasound. <h3>Purpose</h3> We observed striking similarities in shape and magnitude between M-mode diaphragmatic displacement, Pes and Pdi pressures. The study aimed to evaluate if the information provided by these two pressures could be obtained non-invasively from the diaphragmatic displacement curve. <h3>Material and methods</h3> In 14 consecutive intubated patients undergoing a weaning trial, simultaneous recordings of Pes and Pdi pressures and the diaphragmatic displacement were assessed while breathing spontaneously and during a sniff-like manoeuvre. Moreover, the slope of the diaphragmatic displacement curve during relaxation was compared with the maximal relaxation rate (MRR) obtained from the Pdi curve. <h3>Results</h3> More than 200 breaths were analysed in pairs. Diaphragmatic displacement significantly correlated with Pdi (R²=0.33, p&lt;0.001) and Pes (R²=0.44, p&lt;0.001), and this correlation further improved during sniff (R²=0.47, p&lt;0.001) and (R²=0.64, p&lt;0.001), respectively. Additionally, a significant correlation was found between the relaxation slope derived from the diaphragmatic displacement curve and the MRR derived from the Pdi curve, both in normal breathing (R²=0.379, p&lt;0.001) and during the sniff manoeuvre (R²=0.71, p&lt;0.001). <h3>Conclusions</h3> M-mode diaphragmatic displacement parameters correlate well with the ones obtained from oesophageal pressure and Pdi, particularly during sniffing. Diaphragmatic displacement assessment possibly offers an alternative non-invasive solution for understanding and clinically monitoring the diaphragmatic contractile properties and weaning failure due to diaphragmatic fatigue.