Abstract
The prostate gland contains a number of neuropeptides secreted by either autonomic and sensory nerve terminals or the neuroendocrine cells. Among various neuropeptides, bombesin and its mammalian homologue GRP have been implicated in promoting tumor growth and progression in various models of prostate cancer. Furthermore, in our previous studies GRP also increased the invasive capacity and haptotactic migration of PC-3, DU-145, and LNCaP prostate cancer cells 1 Nagakawa O. Ogasawara M. Fujii H. et al. Effect of prostatic neuropeptides on invasion and migration of PC-3 prostate cancer cells. Cancer Lett. 1998; 133: 27-33 Abstract Full Text Full Text PDF PubMed Scopus (71) Google Scholar , 2 Nagakawa O. Ogasawara M. Jun M. et al. Effect of prostatic neuropeptides on migration of prostate cancer cell lines. Int J Urol. 2001; 8: 65-70 Crossref PubMed Scopus (56) Google Scholar and induced the expression of membrane type 1 matrix metalloproteinase protein in DU-145 cells. 3 Nagakawa O. Murakami K. Yamaura T. et al. Expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) on prostate cancer cell lines. Cancer Lett. 2000; 155: 173-179 Abstract Full Text Full Text PDF PubMed Scopus (63) Google Scholar These results indicate that GRP can play an important role in the regulation of the growth and invasion of prostate cancer. Thus, we attempted to clarify whether serum levels of ProGRP (31–98) could be a useful marker in patients with prostatic carcinoma.
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