Abstract
We have reported in this journal that plasma angiotensin II was associated with body weight, was decreased during weight loss, and was associated with adipocyte-derived factors and insulin resistance in obese subjects with type 2 diabetes mellitus [ [1] Saiki A. Ohira M. Endo K. et al. Circulating angiotensin II is associated with body fat accumulation and insulin resistance in obese subjects with type 2 diabetes mellitus. Metabolism. 2009; 58: 708-713 Abstract Full Text Full Text PDF PubMed Scopus (57) Google Scholar ]. The letter from Drs Fetissov and Thornton gave sophisticated comments and good suggestions for our work. They have commented that, in obesity and type 2 diabetes mellitus, hypovolemia and extracellular dehydration were observed and the mechanism was tightly linked with the renin-angiotensin system [ 2 Fetissov S. Nicolaidis S. Neuropeptide Y in the magnocellular hypothalamic neurons of obese Zucker rats. Neuropeptides. 1998; 32: 63-66 Abstract Full Text PDF PubMed Scopus (12) Google Scholar , 3 Thornton S.N. Even P.C. van Dijk G. Hydration increases cell metabolism. Int J Obes (Lond). 2009; 33: 385 Crossref PubMed Scopus (19) Google Scholar ]. Furthermore, they have cited an article that mentioned that cell volume regulation would be dependent on body hydration state and that the cellular dehydration impaired insulin signaling and might be a major cause of insulin resistance [ [4] Schliess F. Häussinger D. Cell volume and insulin signaling. Int Rev Cytol. 2003; 225: 187-228 Crossref PubMed Scopus (49) Google Scholar ]. We also agree with their theory that the increase in plasma angiotensin II and insulin resistance in obesity and type 2 diabetes mellitus may be derived from cellular dehydration and cell reduction. However, no report has been published regarding the relationship between angiotensin II and cellular dehydration in adipocyte. Hypovolemia-induced obesity and diabetesMetabolism - Clinical and ExperimentalVol. 58Issue 11PreviewThe article by Saiki and colleagues [1] published in the Metabolism entitled “Circulating angiotensin II is associated with body fat accumulation and insulin resistance in obese subjects with type 2 diabetes mellitus” is very interesting in that it points out clearly the association between circulating angiotensin levels and the pathophysiology of obesity and diabetes. At first glance, this is rather unusual, as why would a hormone intimately implicated in cardiovascular and water balance functions be involved with fat accumulation and insulin resistance. Full-Text PDF
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