Abstract
Studies of diploid Chinese hamster cells synchronized by mitotic selection suggest that the very earliest DNA to be replicated is relatively AT-rich. There is then a shift to GC-richness as the bulk of the euchromatin is replicated, followed by a return to relative AT-richness as heterochromatin begins to be synthesized later in the S period. These and other observations suggest that the shift in base composition of DNA replicated during the latter part of the S period is a reflection of the distinct types of DNA present in heterochromatin. The frequent appearance of subcomponents in the curves of pulse-labeled DNA centrifuged in cesium chloride suggest there are families of DNA sequences of similar base composition that tend to replicate at similar times.
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