Abstract
Abstract Inhibition of polyoma DNA synthesis by hydroxyurea appears to affect the initiation of new rounds of DNA synthesis to a lesser extent than chain elongation. Viral DNA synthesized in hydroxyurea-treated 3T6 cultures showed an accumulation of early replicative intermediates, in which the progeny strands were shorter than 20% of the genome length. No such accumulation was found for polyoma DNA replicating in control cells, where the replicative intermediates were evenly distributed at all stages of replication.
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