Abstract
Cells nonproductively transformed by the S +L − strain of Moloney (M) murine sarcoma virus (MSV) express three gag gene components, p15, p12, and p30, in the form of a 55,000 molecular weight precursor polyprotein. In addition, these transformed cell lines are characterized by expression of an envelope glycoprotein containing antigenic determinants related to those of both Moloney murine leukemia virus (MuLV) and viruses of the previously described highly leukemogenic mink cell focus-forming (MCF) group. Such cells lack detectable reactivity in competition immunoassays for either the carboxy-terminal gag gene protein, p10, or the type C viral reverse transcriptase. Cells transformed by either of two other M-MSV isolates were found to lack detectable levels of expression of any of the known gag or env gene-coded proteins. These findings indicate that while recombination within type C virus structural genes may be involved in the genesis of mammalian sarcoma viruses, expression of viral structural proteins is not necessary for malignant transformation.
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