Replacement of excretory kidney function by high-efficiency hemodiafiltration (HDF) with a peptide-permeable membrane.

Abstract

Despite considerable progress in dialysis technology in the last decade clinical progress in chronic dialysis patients was absent or neglectable. The National Cooperative Dialysis Study reveilled that morbidity in pts on MHD increased when removal of small uremic solutes was inadequate1. The lower limit for dialysis adequacy, as measured by urea kinetics, was a clearance times time product divided by urea distribution volume (Kt/V), which was 0.8 or lower. Thus, morbidity appears to be interrelated to a definable degree of urea removal. On the other hand, such a relationship cannot be demonstrated when solely an improved removal of “middle molecules” (index: Vit. B12) was obtained2.KeywordsUremic ToxinDialysis AdequacyChronic Dialysis PatientMiddle MoleculeUrea RemovalThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.