Abstract
Hyperlipidemia, one of the cardiovascular (CV) risk factors, is associated with an increase in the risk for dementia. Repetitive transcranial magnetic stimulation (rTMS) was applied over the right dorsolateral prefrontal cortex (DLPFC) to modulate serum lipid levels in older adults. Participants received 10 sessions of rTMS or sham stimulation intervention within 2 weeks. The serum lipid and thyroid hormone-related endocrine levels were assessed before and after the treatment. We found that rTMS significantly decreased serum lipid levels, including the total cholesterol (CHO) and triglyceride (TG); meanwhile, it also increased the thyroid-stimulating hormone (TSH) as well as thyroxine (T4) levels. This suggests that rTMS modulated the serum lipid metabolism by altering activity in the hypothalamo-pituitary-thyroid (HPT) axis. The trial was registered on the website of Chinese Clinical Trial Registry (http://www.chictr.org.cn).
Highlights
Cardiovascular (CV) risk factors, such as hyperlipidemia, diabetes and hypertension, are associated with increased risk of dementia in older adults (Chuang et al, 2014)
The blood lipid levels between the two groups had no statistical difference at baseline (p > 0.05)
10 Hz of Repetitive transcranial magnetic stimulation (rTMS) was applied to healthy older adults with normal baseline lipid levels
Summary
Cardiovascular (CV) risk factors, such as hyperlipidemia, diabetes and hypertension, are associated with increased risk of dementia in older adults (Chuang et al, 2014). Kloppenborg et al (2008) reviewed the evidence for the association of CVD risk factors, including dyslipidemia, obesity, diabetes and hypertension with dementia. Epidemiological studies proposed that high total serum cholesterol in midlife is linked to sporadic AD in old age (Notkola et al, 1998). Lipid measures, such as high-density lipoproteins (HDL) and total cholesterol (Kivipelto et al, 2006; Reitz et al, 2010), are currently used as assessment tools to evaluate the risk of AD and dementia This suggests that vascular risk factors, especially blood lipids, should be regarded as a major target for preventive measures later in life
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