Abstract
Repetitive Transcranial Magnetic Stimulation Improves Neurological Function after Cerebral Ischemia in Rats by Increasing CREB-Regulated TrkB <i>via</i> Activation of cAMP/PKA and Ca <sup>2+</sup>/CaMKIV Signaling Pathways
Highlights
Cerebral ischemia is the most prevalent form of clinical stroke
The above results suggested that the rat model of permanent focal cerebral ischemia was successfully established, which was characterized by most obvious cortical changes
In order to evaluate whether Repetitive transcranial magnetic stimulation (rTMS) stimulation could improve the neurological function of middle cerebral artery occlusion (MCAO) rats, the neurobehavioral changes in rats were examined at days 1, 3, 7 and 14 after injury
Summary
Repetitive transcranial magnetic stimulation (rTMS) can modulate excitability of the cerebral cortex, and this effect is maintained after the stimulation is terminated. The underlying mechanisms of rTMS in cerebral ischemia remain unclear. Cerebral ischemia is the most common stroke inducer, which is characterized by reduced blood flow to brain tissues, causing insufficient transport of glucose, oxygen and other nutrients, and resulting in metabolic changes and possibly cell death [1]. Neurological deficits induced by cerebral ischemia reperfusion injury were frequently detected after the blood flow was restored in patients with cerebral stroke [4]. Repetitive transcranial magnetic stimulation (rTMS) as a therapeutic approach for functional recovery of subacute cerebral ischemia has been linked to an anti-apoptotic mechanism in the peri-ischemic area [6]
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