Abstract
Syndrome specific repetitive behavior profiles have been described previously. A detailed profile is absent for Rubinstein-Taybi syndrome (RTS). The Repetitive Behaviour Questionnaire and Social Communication Questionnaire were completed for children and adults with RTS (N = 87), Fragile-X (N = 196) and Down (N = 132) syndromes, and individuals reaching cut-off for autism spectrum disorder (N = 228). Total and matched group analyses were conducted. A phenotypic profile of repetitive behavior was found in RTS. The majority of behaviors in RTS were not associated with social-communication deficits or degree of disability. Repetitive behavior should be studied at a fine-grained level. A dissociation of the triad of impairments might be evident in RTS.
Highlights
IntroductionSyndromespecificrepetitivebehaviorprofileshavebeendescribedpreviously. AdetailedprofileisabsentforRubinstein-Taybisyndrome(RTS). Method. TheRepetitiveBehaviourQuestionnaireandSocialCommunicationQuestionnaire (SCQ)werecompletedforchildrenandadultsRTS(N=87),Fragile-X(N=196)andDown (N=132)syndromes,andindividualsreachingcut-offforAutismSpectrumDisorder(ASD) (N = 228). Results. Totaland matchedgroupanalyses wereconducted. Aphenotypicprofileof repetitivebehaviorwasfoundinRTS. ThemajorityofbehaviorsinRTSwerenotassociated withsocial-communicationdeficitsordegreeofdisability. Conclusions. Repetitivebehaviorshouldbestudiedatafine-grainedlevel. Adissociationof thetriadofimpairmentsmightbeevidentinRTS
Oliver, Arron, Burbidge and Berg (2009) used a fine-grained approach to study repetitivebehaviorinsevenneurodevelopmentaldisorders,notincludingRTS,andfound significantgroupdifferences,manyofwhichwereunrelatedtodegreeofdisability. These findings suggest that a fine grained approach to studying repetitive behavior in other syndromesmightrevealphenotypicrepetitivebehaviorprofiles.Forexample,individuals withFragile-Xsyndrome(FXS)weremorelikelytoengageinagreaternumberof topographiesofrepetitivebehaviorincomparisontoothersyndromegroupsandthemajority ofthesebehaviorsoccurredmorefrequentlythanatleasttwogroups.Incontrast,individuals withPrader-Willisyndromeshowedamixedprofileandengagedinhoardingandadherence toroutinemorefrequentlythanatleasttwoothergroups.Inaddition, Mossetal.found syndromespecificrepetitivebehaviorsinSmith-Magenis(SMS)andCriduChatsyndromes: astrongpreferenceforaparticularpeopleandattachmenttospecificobjectsrespectively
Previous research has found that specific repetitive behavior profiles can be described for a rangeofneurodevelopmentaldisorders,lendingsupportforstudyingrepetitivebehaviorata fine-grainedlevelofdescription(Turner,1997; Mossetal.,2009).Inaddition,repetitive behaviorhasbeenlinkedtosocial-communicationdeficits,associatedwithASD,andability level(WorldHealthOrganisation,1993;AmericanPsychiatricAssociation,1994; McClintocketal.,2003).InthispaperwedescribedtherepetitivebehaviorprofileofRTSin relationtoASD,DSandFXS
Summary
Syndromespecificrepetitivebehaviorprofileshavebeendescribedpreviously. AdetailedprofileisabsentforRubinstein-Taybisyndrome(RTS). Method. TheRepetitiveBehaviourQuestionnaireandSocialCommunicationQuestionnaire (SCQ)werecompletedforchildrenandadultsRTS(N=87),Fragile-X(N=196)andDown (N=132)syndromes,andindividualsreachingcut-offforAutismSpectrumDisorder(ASD) (N = 228). Results. Totaland matchedgroupanalyses wereconducted. Aphenotypicprofileof repetitivebehaviorwasfoundinRTS. ThemajorityofbehaviorsinRTSwerenotassociated withsocial-communicationdeficitsordegreeofdisability. Conclusions. Repetitivebehaviorshouldbestudiedatafine-grainedlevel. Adissociationof thetriadofimpairmentsmightbeevidentinRTS.
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