Abstract
AbstractAdult male rats were treated daily with scopolamine (10 mg/kg) for two weeks and the ACTH response to acute physostigmine (0.1 mg/kg) challenge was evaluated. Although physostigmine produced a significant increase in A CTH concentrations in all animals, repeated scopolamine administration did not alter basal ACTH concentrations or the ACTH response to physostigmine. The results are discussed in relation to dysregulation of the hypothalamic‐pituitary adrenal (HPA) axis and rapid eye movement (REM) sleep in depression, as mediated by differential adaptive responses of central cholinergic systems. Depression 1:101–104 (1993). © 1993 Wiley‐Liss, Inc.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
