Repeated injection of GnRH agonist for triggering final oocyte maturation in patients at high risk of OHSS in GnRH antagonist protocol: a prospective, cohort study

Abstract

Gonadotropin-releasing hormone (GnRH) agonist is sufficient for triggering final oocyte maturation in GnRH antagonist protocol and can significantly reduce incidence of ovarian hyperstimulation syndrome(OHSS) in high-risk patients. However, lower oocyte yield was reported in patients with lower LH level post trigger with single injection of GnRH agonist, which might be related to the shorter duration and lower amount of LH induced by GnRH agonist. Our aim is to study repeated injection of GnRH agonist for preventing OHSS and maintain clinical outcome in high risk patients who receive controlled ovarian stimulation (COS) in GnRH antagonist protocol.