Abstract
The potential exists for humans to be repeatedly or chronically exposed by inhalation to radionuclides in relatively insoluble forms; however, only limited experimental data are available on the effects of such exposures. Female mice were repeatedly exposed by inhalation at approximately 60-day intervals for 1 year to /sup 144/CeO/sub 2/ to reestablish lung burdens of either 0.2, 1.0, or 4.5 ..mu..Ci of /sup 144/Ce to determine the effect of repeated exposure on /sup 144/Ce retention and dosimetry. The long-term effective retention half-times of /sup 144/Ce in the lung, liver, and skeleton after the last repeated inhalation exposure were similar to those in mice exposed once by inhalation to /sup 144/CeO/sub 2/. A mathematical simulation model was developed as an alternative method of describing the pulmonary clearance of /sup 144/Ce after repeated exposures by inhalation to aerosols of /sup 144/CeO/sub 2/. The cumulative radiation doses to the lungs, livers, and skeletons of the repeatedly exposed mice were similar to those which would have occurred had the total lung burden been achieved by a single exposure. The repeatedly exposed mice also had temporal radiation dose patterns to the lung similar to beagle dogs exposed once.
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