Abstract
In a complementary set of studies, we found that nine days of electroconvulsive shock (ECS) sensitized opiate-naive rats to the acute effects of a single morphine injection and, conversely, the induction of morphine tolerance by morphine pellet implantation sensitized ECS-naive rats to the acute opiate-like effects of a single ECS. Colonic temperatures were significantly elevated and body weight gains were significantly diminished in the repeated ECS group 24 hrs following the final ECS treatment. Likewise, morphine pellet implantation for three days resulted in significantly elevated colonic temperatures and decreased body weight gains. The cross-sensitivity between repeated ECS and morphine tolerance as well as the common effects of these two procedures on body weight and colonic temperature suggests that the physiological changes following repeated ECS and the induction of morphine tolerance may share common neurobiological mechanisms.
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