Abstract
BackgroundPredictive models have revealed promising results for the individual prognosis of treatment response and relapse risk as well as for differential diagnosis in affective disorders. Yet, in order to translate personalized predictive modeling from research contexts to psychiatric clinical routine, standardized collection of information of sufficient detail and temporal resolution in day-to-day clinical care is needed. Digital collection of self-report measures by patients is a time- and cost-efficient approach to gain such data throughout treatment.ObjectiveThe objective of this study was to investigate whether patients with severe affective disorders were willing and able to participate in such efforts, whether the feasibility of such systems might vary depending on individual patient characteristics, and if digitally acquired assessments were of sufficient diagnostic validity.MethodsWe implemented a system for longitudinal digital collection of risk and symptom profiles based on repeated self-reports via tablet computers throughout inpatient treatment of affective disorders at the Department of Psychiatry at the University of Münster. Tablet-handling competency and the speed of data entry were assessed. Depression severity was additionally assessed by a clinical interviewer at baseline and before discharge.ResultsOf 364 affective disorder patients who were approached, 242 (66.5%) participated in the study; 88.8% of participants (215/242) were diagnosed with major depressive disorder, and 27 (11.2%) had bipolar disorder. During the duration of inpatient treatment, 79% of expected assessments were completed, with an average of 4 completed assessments per participant; 4 participants (4/242, 1.6%) dropped out of the study prematurely. During data entry, 89.3% of participants (216/242) did not require additional support. Needing support with tablet handling and slower data entry pace were predicted by older age, whereas depression severity at baseline did not influence these measures. Patient self-reporting of depression severity showed high agreement with standardized external assessments by a clinical interviewer.ConclusionsOur results indicate that digital collection of self-report measures is a feasible, accessible, and valid method for longitudinal data collection in psychiatric routine, which will eventually facilitate the identification of individual risk and resilience factors for affective disorders and pave the way toward personalized psychiatric care.
Highlights
In what has become known as P4 or precision medicine [1,2] a major goal of medical research and applied health care is the evolution from a reactive treatment approach toward medical care that is predictive, preventative, personalized, and participatory.This approach is relevant in the field of psychiatry, as the imprecise nature of psychiatric nosology, in part due to the heterogeneity of clinical populations, complicates the identification of vulnerable groups and effective treatments [3,4]
We implemented a system for longitudinal digital collection of risk and symptom profiles based on repeated self-reports via tablet computers throughout inpatient treatment of affective disorders at the Department of Psychiatry at the University of Münster
All 242 participants were diagnosed with an affective disorder
Summary
In what has become known as P4 or precision medicine [1,2] a major goal of medical research and applied health care is the evolution from a reactive treatment approach toward medical care that is predictive, preventative, personalized, and participatory. This approach is relevant in the field of psychiatry, as the imprecise nature of psychiatric nosology, in part due to the heterogeneity of clinical populations, complicates the identification of vulnerable groups and effective treatments [3,4]. Digital collection of self-report measures by patients is a time- and cost-efficient approach to gain such data throughout treatment
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