Repeatability of Spectral Domain Optical Coherence Tomography Measurements of Bruch's Membrane Opening-Minimum Rim Width in Epiretinal Membrane Patients with Peripapillary Involvement.

Ki Yup Nam,Bum Jun Kim,Yong Seop Han,Woo Hyuk Lee

doi:10.3390/jcm10112240

Abstract

The Bruch’s membrane opening-minimum rim width (BMO-MRW) is a recently introduced parameter of the neuroretinal rim. We analyzed the repeatability of spectral-domain optical coherence tomography (SD-OCT) measurements of BMO-MRW in epiretinal membrane (ERM) patients with peripapillary involvement, since the surface around the optic disc is distorted in such patients. BMO-MRW and retinal nerve fiber layer (RNFL) thickness measurements were performed using SD-OCT in prospectively enrolled ERM patients and age-matched healthy control individuals. After two consecutive measurements with a 5 min interval, repeatability was analyzed using the intraclass correlation coefficient (ICC), repeatability coefficient (RC), and coefficient of variation (CV). Fifty-two eyes of 52 ERM patients and 62 eyes of 62 healthy controls were included in the study. The ICCs of the mean BMO-MRW/RNFL thickness measurements were 0.999/0.985 in ERM eyes and 0.999/0.999 in normal eyes, respectively. The RC values of mean BMO-MRW/RNFL thickness measurements were 9.0/6.25 μm in ERM eyes and 4.61/0.92 μm in normal eyes, respectively. The CV values were 0.91% and 1.45% for BMO-MRW and RNFL thickness in ERM eyes, and 0.63% and 0.33% in normal eyes, respectively. In ERM eyes, the RC, CV of average BMO-MRW were 1.9 and 1.4 times greater than those of normal eyes, but 6.8 and 4.4 times greater for average RNFL thickness. BMO-MRW and RNFL thickness showed good repeatability in the diseased eyes with peripapillary involvement and healthy control eyes. Based on the ICC, RC, and CV values, the repeatability of BMO-MRW measurements in peripapillary membrane patients was better than that of RNFL thickness.

Highlights

Several studies reported that Bruch’s membrane opening-minimum rim width (BMO-MRW) has higher diagnostic utility for glaucoma than the rim area measured by confocal laser tomography or retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography (OCT), and it has a better correlation with the results of visual field examination [2,3,4,5,6]
Primary angle-closure glaucoma has a prevalence of approximately 5% in patients ≥ 40 years old, and Epiretinal membrane (ERM) is present in 2–10% of these patients [7,8,9,10,11,12]
The present study investigated the repeatability of BMO-MRW and RNFL thickness measurements in ERM patients with peripapillary involvement compared to healthy controls

Summary

Introduction

Reis et al [1] defined BMO as the optic nerve head rim boundary and introduced the minimum distance from the BMO to the internal limiting membrane (ILM) as a new factor for optic disc analysis. Several studies reported that BMO-MRW has higher diagnostic utility for glaucoma than the rim area measured by confocal laser tomography or retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography (OCT), and it has a better correlation with the results of visual field examination [2,3,4,5,6]. Spectral domain optical coherence tomography (SD-OCT) parameters, such as BMOMRW and peripapillary RNFL thickness, may show discrepancies in the same patient, and these parameters may show differences among repeated examinations in the same patient. If ERM involves the peripapillary area, automatic segmentation of the ILM may be affected by changes in the retinal surface

Methods

Results

Conclusion