Abstract
To determine the repeatability of superficial vessel density measurements using Spectral domain Ocular coherence tomography angiography(SD-OCTA) in patients diagnosed with retinal vein occlusion(RVO). Prospective observational study. Patients who visited our retinal clinic from August 2017 to August 2018, diagnosed with RVO were recruited for the study. Two consecutive 3×3 mm pattern scans were performed using the Cirrus HD-OCT 5000 along with AngioPlex software (Carl Zeiss Meditec) in each eye by single skilled examiner. All scans were analyzed using en face OCTA images to measure vessel density (VD) automatically. For further analysis of the effect of central macular thickness(CMT), eyes were divided into two groups according to CMT of 400μm (Group 1: CMT > 400μm, Group 2: CMT < 400μm). To identify factors affecting the repeatability of VD measurements, linear regression analyses were conducted for the coefficient of variation (CV) of VD by investigating demographics and ocular variables. The intraclass correlation coefficient (ICC), coefficient of variation (CV) of VD measurements. A total of 57 eyes from 57 patients were examined: 35 eyes with BRVO and 22 eyes with CRVO. In all 57 eyes with RVO, the ICC and CV of the full VD(VD of 3mm diameter circle) were 0.800 and 10.61%, respectively. Univariate analyses showed that the mean CMT (B, 0.001; p<0.001) and mean ganglion cell-Inner plexiform layer (GC-IPL) thickness (B, -0.002; p = 0.020) were significant factors that affected the repeatability. Multivariate analyses of these two factors showed that only mean CMT was a significant factor. The ICC and CV of the full VD in group 1 (CMT > 400μm) were 0.348 and 22.55% respectively. In group 2 (CMT < 400μm), the ICC and CV of the full VD were 0.910 and 7.76%, respectively. The repeatability of VD measurement in eyes with RVO was reasonably comparable to previous studies. Repeatability of VD measurement was significantly affected by central macular thickness.
Highlights
Retinal vein occlusion (RVO) is the second most common retinal vascular disease after diabetic retinopathy
To identify factors affecting the repeatability of vessel density (VD) measurements, linear regression analyses were conducted for the coefficient of variation (CV) of VD by investigating demographics and ocular variables
Univariate analyses showed that the mean CMT (B, 0.001; p
Summary
Retinal vein occlusion (RVO) is the second most common retinal vascular disease after diabetic retinopathy. Given the prevalence of the aging population throughout the world, the accurate diagnosis and adequate management of RVO have become critically important [3,4,5,6]. OCTA provides quantitative metrics of the retinal microvasculature such as vessel density (VD), perfusion density, and the foveal avascular zone (FAZ) area of the retinal capillary plexus [7,8,9,10,11]. Even though OCTA has several limitations such as projection artifacts and narrow field of view, this novel technique can provide clinicians with microvascular information that can assist diagnosis and treatment of many types of retinal vascular diseases [12, 13]
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