Repeatability of automatic measurements by a new anterior segment optical coherence tomographer combined with Placido topography and agreement with 2 Scheimpflug cameras

Abstract

To evaluate the repeatability of automatic measurements by a new anterior segment optical coherence tomographer (AS-OCT) combined with Placido topography and their agreement with those provided by 2 rotating Scheimpflug cameras. G.B. Bietti Foundation IRCCS, Rome, Italy. Evaluation of a diagnostic test instrument. Unoperated eyes and eyes with previous myopic excimer laser surgery were analyzed. Three consecutive scans were acquired with an AS-OCT device (MS-39) and 1 with 2 rotating Scheimpflug cameras (Pentacam HR and Sirius). The following parameters were evaluated: simulated keratometry, posterior and total corneal power, total corneal astigmatism, corneal asphericity, thinnest corneal thickness, central epithelial thickness, corneal diameter, and aqueous depth. Repeatability was assessed using test-retest variability, the coefficient of variation (CoV), and the intraclass correlation coefficient; agreement was assessed by the 95% limits of agreement. The study comprised 96 unoperated eyes and 43 eyes with previous myopic excimer laser surgery. High repeatability was achieved in both groups, as shown by a CoV less than 1.0% for most parameters. The repeatability of epithelial thickness was slightly lower than that of the whole corneal thickness, although the CoV was still good (1.87% in unoperated eyes; 3.28% in post-refractive surgery eyes). Moderate repeatability was found for total corneal astigmatism measurements, with a CoV greater than 20.0%. Agreement with Scheimpflug cameras was high for aqueous depth and thinnest corneal thickness and moderate for most other parameters. The high repeatability of automatic measurements by the new AS-OCT device supports its use in clinical practice.