Repeatability and reproducibility of anterior ocular biometric measurements with 2-dimensional and 3-dimensional optical coherence tomography

Abstract

To evaluate the repeatability and reproducibility of central corneal thickness (CCT), anterior chamber depth (ACD), and anterior chamber width (ACW) measurements using 3-dimensional (3-D) corneal and anterior segment optical coherence tomography (CAS-OCT) and 2-dimensional (2-D) anterior segment OCT (AS-OCT). Department of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan. Nonrandomized clinical trial. The CCT, ACD, and ACW were measured in normal eyes using a prototype 3-D swept-source CAS-OCT device and a 2-D time-domain AS-OCT device (Visante). The coefficient of repeatability and reproducibility and the intraclass correlation coefficient (ICC) were calculated to evaluate the repeatability and reproducibility of the measurements. Eighty-five eyes (85 subjects) were evaluated. The mean CCT measurement was 557.5 μm ± 40.5 (SD) with CAS-OCT and 556.4 ± 39.4 μm with AS-OCT; the mean ACD measurement, 3.13 ± 0.40 mm and 3.16 ± 0.39 mm, respectively; and the mean ACW, 11.80 ± 0.47 mm and 11.79 ± 0.49 mm, respectively. There was no statistically significant difference in CCT or ACW measurements between the 2 devices (P>.05, Wilcoxon signed rank test). Although the ACD measurements were significantly different (P<.0001), the difference was small (0.03 mm). Significant linear correlations were found between the measurements of the 2 devices (P<.0001). The ICC was greater than 0.99 for CAS-OCT and greater than 0.96 for AS-OCT. Corneal and anterior segment OCT and AS-OCT provided comparable and well-correlated anterior ocular biometric measurements, with sufficient repeatability and reproducibility.