Abstract
The purpose of this study was to develop a feasible approach for repairing periodontal bone defects with the in vivo tissue engineering bone incorporated with bioabsorbable PLA membrane and to provide evidences for the clinical application. Osteoinductive HA/β-TCP sintered at 1100°C were implanted in the femur medial muscles in the hind legs of three dogs. Four weeks after implantation, the in vivo tissue engineering (TE) bone was explanted. Meanwhile, artificial periodontal bone defects of 8mm×6mm were performed on the buccal side of 4th premolar and 1st molar of mandible bilaterally, with the exposure of dental roots. The defects were treated as follows: (1) in vivo TE bone and PLA membrane; (2) HA/β-TCP ceramics and PLA membrane; (3) PLA membrane only; (4) empty control. At the 2, 4, 8 weeks post-transplantation, the dogs were sacrificed. The specimen were harvested and evaluated by gross inspection, dental radiography, SPECT (99mTC-MDP) and histological observation by MPIA2500. The results showed that more mature osseointegration was found in the group 1. We presumed that the in vivo TE bone graft could enhance the reparation of periodontal bone defects.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
