Abstract
This study aims to analyze the improvement of the histopathological picture of renal tubules in diabetic rats after being given golden sea cucumber extract (Stichopus hermanii). This research uses experimental design laboratories with a post-test only control group design method. The sampling used simple random sampling with 25 white rats divided into five groups, namely groups that were given standard feed without STZ-induced, STZ-induced group, STZ-induced group and given golden sea cucumber extract at a dose of 4.25 mg/kg BW for 21 days, STZinduced group and given golden sea cucumber extract at a dose of 8.5 mg/kg BW for 21 days, and STZ-induced group and given gold sea cucumber extract at a dose of 12.75 mg/kg BW for 21 days. The data on the observation of each group's kidney histopathology was carried out at the end of the session. The results of the analysis using the Kruskal-Wallis Test showed significant results, the Mann-Whitney Test showed significant differences between the STZinduced group and the golden sea cucumber extract (Stichopus hermanii) dose of 12.75 mg/kg BW (x=7.4 mg/dl) decreased significantly (p=0.001) compared to the STZ-only-induced group (x=12.6 mg/dl). Administration of golden sea cucumber extract (Stichopus hermanii) at a dose of 12.75 mg/kg BW of rats for 21 days lowered the degree of tubular damage to the kidney rectus of white rats (Rattus norvegicus) male streptozotocin-induced strains.
Highlights
Diabetes is one of the largest diseases suffered by the world's population
This study aims to analyze the improvement of the histopathological picture of renal tubules in diabetic rats after being given golden sea cucumber extract (Stichopus hermanii)
The sampling used simple random sampling with 25 white rats divided into five groups, namely groups that were given standard feed without STZ-induced, STZ-induced group, STZ-induced group and given golden sea cucumber extract at a dose of 4.25 mg/kg BW for 21 days, STZinduced group and given golden sea cucumber extract at a dose of 8.5 mg/kg BW for 21 days, and STZ-induced group and given gold sea cucumber extract at a dose of 12.75 mg/kg BW for 21 days
Summary
Diabetes is one of the largest diseases suffered by the world's population. Today, approximately 422 million people with Diabetes who are 18 years old worldwide or 8.5% of the entire world population[1,2,3]. 20-30 percent of people with diabetes mellitus will experience diabetic nephropathy, which becomes chronic renal failure[5]. Damayanti research shows that golden sea cucumber water extract contains antioxidant content beneficial to the body, such as flavonoids, saponins, amino acids, zinc minerals, and others[11]. Based on the study above, this study analyzed improvements in the histopathological picture of tubules renal kidneys in diabetic rats after being given golden sea cucumber extract (Stichopus hermanii). Repairing of Renal Tubules in Diabetic Rats (Rattus norvegicus) Diabetes After Administration of Golden Sea Cucumber (Stichopus hermanii). Setianingsih, et al.: Repairing of Renal Tubules in Diabetic Rats (Rattus norvegicus) Diabetes After Administration of Golden Sea Cucumber (Stichopus hermanii)
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