Repair, Removal, and Shutdown: It All Hinges on RNA Polymerase II Ubiquitylation

Abstract

Two papers, by Nakazawa and Vidaković, show how ubiquitylation of a single lysine residue in RNA polymerase II serves as a master switch to regulate transcription, RNA polymerase II degradation, and transcription-coupled nucleotide excision repair in response to DNA damage.