Abstract

Large zones of coagulation necrosis were produced in the cerebral hemispheres of rodents by burning the intact skull. Mice and guinea pigs responded weakly, with relatively few macrophages and slow vascular proliferation. Rats, gerbils, and hamsters responded more rapidly and with far more macrophages. Vascular and reticulin proliferation was especially notable in hamsters. In addition to the large interspecies differences, there were small intraspecies differences among inbred strains of mice but not among rats. Sex, adrenal factors, and genetic disposition to high or low total blood leukocyte counts were not responsible for these differences. Age had a minor role. Further comparative anatomical studies may increase the understanding of repair of brain injuries.

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