Abstract
Abstract Neovascularization was induced surgically in normally avascular canine corneas to study the repair of sublethal damage in slowly proliferating capillary endothelial cells. Neovascularization was stimulated for 7 days after split dose treatments with 6 Co γ-rays. Corneal tissue samples were evaluated by quantitative morphometric methods. A time recovery curve was drawn by plotting per cent capillary volume vs time between two equal doses. A typical Elkind type of time recovery response was observed. A split dose response assay resulted in an incremental dose D 2 — D 1 of 265 rad at the 1% capillary volume level. The results suggest a substantial repair capacity for capillary endothelial cells.
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