Abstract
Osteonecrosis of the femoral head (ONFH) is a common disease with limited options of treatment. In this study, we prepared self-setting nano-sized hydroxyapatite carriers incorporating microspheres for controlled release of growth differentiation factor-5 (GDF-5) and/or alendronate (ALN). GDF-5 release enhanced the proliferation of rabbit bone mesenchymal stem cells (BMSCs), and ALN release inhibited the proliferation of macrophages. A rabbit ONFH model was created by liquid nitrogen infusion, and the carriers were implanted into the channel-shaped defects and harvested at 12 weeks. Imaging examination and histological analyses found that all carriers increased new bone formation in the defects, with the group simultaneously incorporating GDF-5 and ALN yielding the greatest improvement. The synergistic release of ALN and GDF-5 from the carrier may offer a promising option for the treatment of ONFH after surgical decompression. Schematic illustration of sequential release of GDF-5 from PLGA microspheres and alendronate (ALN) from gelatin microspheres embedded in an injectable calcium phosphate/alginate carrier for repairing ONFH
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
