Abstract
Peripheral nerve injury often occurs in young adults and is characterized by complex regeneration mechanisms, poor prognosis, and slow recovery, which not only creates psychological obstacles for the patients but also causes a significant burden on society, making it a fundamental problem in clinical medicine. Various steps are needed to promote regeneration of the peripheral nerve. As a bioremediation material, self-assembled peptide (SAP) hydrogels have attracted international attention. They can not only be designed with different characteristics but also be applied in the repair of peripheral nerve injury by promoting cell proliferation or drug-loaded sustained release. SAP hydrogels are widely used in tissue engineering and have become the focus of research. They have extensive application prospects and are of great potential biological value. In this paper, the application of SAP hydrogel in peripheral nerve injury repair is reviewed, and the latest progress in peptide composites and fabrication techniques are discussed.
Highlights
Peripheral nerve injury (PNI) is mainly caused by surgery and trauma, resulting in sensory, motor, and functional disorders of the affected innervated area
The repair of peripheral nerve injury has always been a complex problem in medicine because of its high incidence, high disability rate, low cure rate, and heavy social and personal burden
In only relying on the traditional treatment of peripheral nerve injury, such as surgery or drugs, it is no longer possible to meet the high requirements to achieve a therapeutic effect in modern patients
Summary
Peripheral nerve injury (PNI) is mainly caused by surgery and trauma, resulting in sensory, motor, and functional disorders of the affected innervated area. The in vivo regeneration mechanism is complex, with slow nerve growth, dislocation growth, and target muscle atrophy, resulting in poor functional recovery; only a small number of people are satisfied with their sensory and motor function recovery, and some patients may even be disabled for life [7,8]. This creates a psychological obstacle for patients and a more significant burden to society [9,10]. The application of different SAP hydrogels in peripheral nerve injury is reviewed, the advantages and disadvantages of various composites are discussed, and possible future directions for the development of nerve repair materials are presented
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