Abstract
Much excellent investigative work has been done in an attempt to determine the processes involved in the healing of bone injuries. Practically none of the reported data deal with those cellular changes which take place within the first forty-eight hours after the creation of the bone defect. In this paper are given the results of experiments designed to determine the early cellular responses to trauma to the bone. The plan followed in studying the processes of bone repair aims to evaluate the relative function and importance of the periosteum, cortex and marrow. Investigation was confined to the repair of induced defects of the midportion of the diaphysis of a typical long bone, the tibia. The white rat was used as it is the laboratory animal which has been most frequently used by other investigators and hence concerning which there exist the most varied and exact data. The animals were raised
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