Abstract
Previous observations on suction blisters have indicated that dermal epidermal adherence is of a viscous nature. However, very small pressure differences over the epidermis generally fail to produce blistering even over extended periods of time. This suggests that a second, nonviscous, element is involved in the adherence of epidermis and dermis. In the present study experiments with interrupted suction were performed. Results demonstrate a process of repair, or regeneration of the adherence, operating with a time constant of less than 1 hr. This process of repair may be described mathematically as an elastic component in the adherence, suggesting the involvement of elastic structures. A process of active reattachment originating from the epidermal cells could also account for the observations. We believe that failure of the repair mechanism, followed in turn by rupture of the viscous bond due to small local pressure differences, may be the cause of some types of experimental and clinical blistering.
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