Abstract
Lesions introduced into the DNA of Chinese hamster cells by dimethyl sulphate (DMS) are recognized by an enzyme(s) present in crude extracts of M. luteus . Such lesions are rapidly lost from DNA during post treatment incubation of cells. The number of these enzyme-sensitive sites in methylated DNA, their rate of loss and their heat lability are consistent with the majority being 3-methyladenine adducts in DNA.
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