Abstract
DNA sequence context and nucleosomal positioning guide the repair efficiency of clustered abasic sites by APE1 enzyme.
Highlights
One of the most common and highly mutagenic types of DNA damage results from the removal of bases from DNA, creating apuridinic or apyrimidinic residues, commonly known as abasic site.[1]
We studied the efficiency of the repair of clustered abasic sites by the APE1 enzyme in nucleosome core particles (NCPs)
The repair of abasic sites in isolation or in clusters is highly in uenced by the sequence context of the concerned DNA.[27]. This prompted us to investigate the processing of clustered abasic sites in the core sequence of TATA box and CpG island in the NCP model
Summary
One of the most common and highly mutagenic types of DNA damage results from the removal of bases from DNA, creating apuridinic or apyrimidinic residues, commonly known as abasic site.[1]. Photochemically induced clustered abasic sites in NCPs have been found to create DNA–histone
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