Repair cell first, then regenerate the tissues and organs

Xiao-Bing Fu

doi:10.1186/s40779-021-00297-5

Abstract

Wound healing, tissue repair and regenerative medicine are in great demand, and great achievements in these fields have been made. The traditional strategy of tissue repair and regeneration has focused on the level of tissues and organs directly; however, the basic process of repair at the cell level is often neglected. Because the cell is the basic unit of organism structure and function; cell damage is caused first by ischemia or ischemia-reperfusion after severe trauma and injury. Then, damage to tissues and organs occurs with massive cell damage, apoptosis and even cell death. Thus, how to achieve the aim of perfect repair and regeneration? The basic process of tissue or organ repair and regeneration should involve repair of cells first, then tissues and organs. In this manuscript, it is my consideration about how to repair the cell first, then regenerate the tissues and organs.

Highlights

Main text The cell is the basic unit of organism structure and function; cell damage is caused first by ischemia or ischemia-reperfusion after severe trauma and injury
The current study identified that a combination of small molecules and growth factors could effectively induce IMR-90 fibroblasts into dopaminergic neuron-like cells that expressed dopaminergic neuron markers and possessed the electrophysiological properties of neurons [3]
What can be used to repair the cells first? As mentioned before, ischemic cell injury is the basic pathological process of tissue injury caused by ischemia or ischemiareperfusion after severe trauma and diseases

Summary

Introduction

Main text The cell is the basic unit of organism structure and function; cell damage is caused first by ischemia or ischemia-reperfusion after severe trauma and injury. The traditional strategy of tissue repair and regeneration has focused on the level of tissue and organs directly; the basic process of repair at the cell level is often neglected. Ischemic-damaged tissues can recover their structure and function after debridement and infection control and are considered the tissues that will play a role in the repair process after debridement.

Results

Conclusion