Abstract

Repair by a molecular DNA ambulance.

Highlights

  • Most of the genome of a eukaryotic cell is located in its nucleus, which is a ball-like entity defined by a membrane bilayer known as the nuclear envelope

  • This analysis revealed that double-strand breaks (DSBs) close to linear chromosome ends, or telomeres, are preferentially repaired via an error-prone type of homologous recombination called break-induced replication (BIR) [7]

  • Genetic and molecular biology experiments revealed that DSB induction greatly increases physical interactions between the damaged chromosome ends and nuclear pore complexes

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Summary

Introduction

Most of the genome of a eukaryotic cell is located in its nucleus, which is a ball-like entity defined by a membrane bilayer known as the nuclear envelope. This analysis revealed that DSBs close to linear chromosome ends, or telomeres, are preferentially repaired via an error-prone type of homologous recombination called break-induced replication (BIR) [7]. Essential to this repair process were inner nuclear membrane proteins that typically work to tether telomeres to the nuclear envelope. Critical to DSB survival was a particular nuclear pore complex.

Results
Conclusion

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