Abstract
Repair by a molecular DNA ambulance.
Highlights
Most of the genome of a eukaryotic cell is located in its nucleus, which is a ball-like entity defined by a membrane bilayer known as the nuclear envelope
This analysis revealed that double-strand breaks (DSBs) close to linear chromosome ends, or telomeres, are preferentially repaired via an error-prone type of homologous recombination called break-induced replication (BIR) [7]
Genetic and molecular biology experiments revealed that DSB induction greatly increases physical interactions between the damaged chromosome ends and nuclear pore complexes
Summary
Most of the genome of a eukaryotic cell is located in its nucleus, which is a ball-like entity defined by a membrane bilayer known as the nuclear envelope. This analysis revealed that DSBs close to linear chromosome ends, or telomeres, are preferentially repaired via an error-prone type of homologous recombination called break-induced replication (BIR) [7]. Essential to this repair process were inner nuclear membrane proteins that typically work to tether telomeres to the nuclear envelope. Critical to DSB survival was a particular nuclear pore complex.
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