Abstract
We have studied the characteristics of the heart in the adult Giant danio (Danio aequipinnatus), the wound repair response and the ability to regenerate following cautery injury. Electron microscopy studies revealed cardiac myocyte ultrastructure and organization similar to that observed in the zebrafish (Danio rerio). Apical cauterization resulted in injury to 25% of the ventricle. The injury initiated a robust inflammatory response with early recruitment of heterophils and mast cells, and the persistence of myeloperoxidase‐positive cells beyond the first week post‐injury. Bromodeoxyuridine and proliferating cell nuclear antigen‐positive cells, including endothelial cells and cardiac myocytes, were present in areas adjacent to the site of injury during the repair process, but primarily in adjacent subepicardial compact heart region by the second week. We observed marked collagen accumulation on day 14 that persisted through day 45. The collagen accumulation did not result in permanent fibrosis but appears to be resolved by 60 days when the ventricle was completely regenerated. Our data suggest that the Giant danio possesses robust repair mechanisms in the ventricle and may serve as an important model of cardiac inflammation, remodeling and regeneration.
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